Vanillic Acid Improve Neural Function after Focal Cerebral Ischemia-reperfusion Rats
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چکیده
منابع مشابه
Folic acid stimulates proliferation of transplanted neural stem cells after focal cerebral ischemia in rats.
Folic acid (FA) stimulates neural stem cell (NSC) proliferation in vitro and enhances hippocampal neurogenesis in rats after middle cerebral artery occlusion (MCAO). The effect of FA supplementation on exogenous NSCs transplanted in MCAO rats was observed to determine if FA can stimulate NSC replacement after focal cerebral ischemia. Rats were randomly assigned to 3 groups: MCAO; MCAO and exoge...
متن کاملInhibition of nitric oxide synthase activity improves focal cerebral damage induced by cerebral ischemia/reperfusion in normotensive rats
Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...
متن کاملReperfusion Promotes Mitochondrial Biogenesis following Focal Cerebral Ischemia in Rats
BACKGROUND AND PURPOSE Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion. Mitochondrial biogenesis causes an increase in the individual mitochondrial mass of neurons and maintains their aerobic set-point in the face of declining function. The aim of this stud...
متن کاملReperfusion Promotes Mitochondrial Dysfunction following Focal Cerebral Ischemia in Rats
BACKGROUND AND PURPOSE Mitochondrial dysfunction has been implicated in the cell death observed after cerebral ischemia, and several mechanisms for this dysfunction have been proposed. Reperfusion after transient cerebral ischemia may cause continued and even more severe damage to the brain. Many lines of evidence have shown that mitochondria suffer severe damage in response to ischemic injury....
متن کاملExpression profiles of microRNAs after focal cerebral ischemia/reperfusion injury in rats☆
Rat models of focal cerebral ischemia/reperfusion injury were established by occlusion of the middle cerebral artery. Microarray analysis showed that 24 hours after cerebral ischemia, there were nine up-regulated and 27 down-regulated microRNA genes in cortical tissue. Bioinformatic analysis showed that bcl-2 was the target gene of microRNA-384-5p and microRNA-494, and caspase-3 was the target ...
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ژورنال
عنوان ژورنال: International Journal of Pharmacology
سال: 2018
ISSN: 1811-7775
DOI: 10.3923/ijp.2018.488.494